Optimal sampling times in bioequivalence studies using a simulated annealing algorithm
نویسندگان
چکیده
منابع مشابه
Optimal sampling times in bioequivalence studies using a simulated annealing algorithm
In pharmacokinetic (PK) studies, blood samples are taken over time on subjects after the administration of a drug to measure the time-course of the plasma drug concentrations. In bioequivalence studies, the trapezoidal rule on the sampled time points is often used to estimate the area under the plasma concentration-time curve, a quantity of principle interest. This manuscript investigates the c...
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ژورنال
عنوان ژورنال: Statistics and Computing
سال: 2007
ISSN: 0960-3174,1573-1375
DOI: 10.1007/s11222-007-9023-1